Hydroxyindole O-methyltransferase controls cancer growth and metastasis
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چکیده
منابع مشابه
Clever-1/stabilin-1 controls cancer growth and metastasis.
PURPOSE Immunosuppressive leukocytes and vasculature are important host cell components regulating tumor progression. Clever-1/Stabilin-1, a multifunctional scavenger and adhesion receptor, is constitutively present on a subset of type II macrophages and lymphatic endothelium, but its functional role in cancer is unknown. EXPERIMENTAL DESIGN Here, we generated full Clever-1 knockout mice and ...
متن کاملLocalization of hydroxyindole-O-methyltransferase in the mammalian pineal gland and retina.
The pineal hormone, melatonin, has been reported to be synthesized in the retina by the enzyme, hydroxyindole-O-methyltransferase (HIOMT). Several laboratories have suggested that melatonin may be involved in photoreceptor outer segment disc shedding, photomechanical movements, and neuromodulation, but the cellular location of the retinal synthesizing enzymes has not been determined yet. Antise...
متن کاملMolecular cloning and nucleotide sequence of cDNA encoding hydroxyindole O-methyltransferase of bovine pineal glands.
Messenger RNA for hydroxyindole O-methyltransferase (EC 2.1.1.4) was partially purified from poly(A)+ RNA isolated from bovine pineal glands by sucrose density gradient centrifugation. The enriched mRNA was used to prepare a cDNA library by use of expression vector lambda gt11. The library was screened with monoclonal antibodies to the enzyme, and three cDNA clones were isolated. These cloned c...
متن کاملSome properties of pineal gland hydroxyindole-O-methyltransferase from black rhinoceros (Diceros bicornis).
Pineal glands were obtained from two young female black rhinoceri that had died as a result of postcapture trauma during a translocation exercise. Hydroxyindole-O-methyltransferase (HIOMT) from these pineal glands showed a peak activity at pH 8.2, although high activity extended over a fairly wide pH range (7.8-8.4). N-acetylserotonin was the best hydroxyindolic substrate for the enzyme, althou...
متن کاملControl of Hydroxyindole O-methyltransferase Activity in the Rat Pineal Gland by Environmental Lighting.
The mammalian plineal rland has been shown to contain several enzymes involved in the formation and metabolism of physiologically active indoles and amines (1-3). The rat plineal (lan(l contains the highest rel)orted tissue levels of serotonin and 5-hvdroxytryptophan decarboxylase (4, 5). In addition, the plineal gland is unique in that it is the only organ that contai ns hydloxvindole O-methvl...
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ژورنال
عنوان ژورنال: Integrative Cancer Science and Therapeutics
سال: 2020
ISSN: 2056-4546
DOI: 10.15761/icst.1000330